Endogenous Fungal Endophthalmitis Developing in a Myasthenia Gravis Individual Treated with High Dose Methylprednisolone

Endogenous fungal endophthalmitis (EFE) is a rare but serious complication of fungal sepsis and the incidence has increased in the past half century because of the advent of antibiotics and indwelling catheters [1]. The most common cause of culture-proven EFE is Candida species [2]. Although a particular therapeutic regimen has not been prospectively established, treatment options can include intraocular, systemic antifungal treatment and vitrectomy. However, fungal endophthalmitis caused by the corticosteroid impulse therapy is less reported. Here, we report, the successful management of fungal endophthalmitis in a patient with multiple diseases and unstable systemic status with oral voriconazole, but cerebral spinal fluid (CSF) and sputum cultures are always negative for fungi.